E-4031 (free base)

E-4031 free base is a selective hERG potassium channel blocker for use in class III anti-arrhythmic studies[1].

Product Specifications

CAS Number

[113558-89-7]

UNSPSC

12352005

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/e-4031-free-base.html

Smiles

CS(=O)(NC1=CC=C(C(C2CCN(CCC3=NC(C)=CC=C3)CC2)=O)C=C1)=O

Molecular Formula

C21H27N3O3S

Molecular Weight

401.52

References & Citations

[1]Daisuke Izumi, et al. Effects of bepridil versus E-4031 on transmural ventricular repolarization and inducibility of ventricular tachyarrhythmias in the dog. Pacing Clin Electrophysiol. 2010 Aug;33 (8) :950-9.|[2]E E Verheijck, et al. Effects of delayed rectifier current blockade by E-4031 on impulse generation in single sinoatrial nodal myocytes of the rabbit. Circ Res. 1995 Apr;76 (4) :607-15.