Thyrotropin
Thyrotropin (TSH, Pretiron) is a thyroid-stimulating hormone produced by thyrotrope cells in the anterior pituitary gland. Thyrotropin regulates the endocrine function of the thyroid. Thyrotropin induces transcriptional regulation of TH-gatekeeper genes in tanycytes through the Tshr/Gαq/PKC pathway. Thyrotropin prevents Apoptosis. Thyrotropin has an association of low levels with increased bone remodeling, reduced bone mass and a high fracture risk in mice. Thyrotropin is promising for research of skeletal remodeling, hyperthyroidism[1][2][3][4][13].
Product Specifications
Product Name Alternative
TSH; Pretiron
UNSPSC
12352211
Target
Apoptosis; PKC; TSH Receptor
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics; GPCR/G Protein; TGF-beta/Smad
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Endocrinology; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/thyrotropin.html
Purity
95
Solubility
10 mM in DMSO
Smiles
[Thyrotropin]
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-107916/Thyrotropin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-107916/Thyrotropin-SDS-MedChemExpress.pdf
Scientific Category
Reference compound1
Clinical Information
Launched
CAS Number
[9002-71-5]
Available Sizes
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