Thyrotropin
Product Specifications
UNSPSC Description
Thyrotropin is a thyroid-stimulating hormone produced by thyrotrope cells in the anterior pituitary gland. Thyrotropin regulates the endocrine function of the thyroid. Thyrotropin induces transcriptional regulation of TH-gatekeeper genes in tanycytes through the Tshr/Gαq/PKC pathway. Thyrotropin has an association of low levels with increased bone remodeling, reduced bone mass and a high fracture risk in mice. Thyrotropin is promising for research of skeletal remodeling, hyperthyroidism[1][2][3][4].
Target Antigen
Others
Type
Reference compound
Related Pathways
Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology; Metabolic Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/thyrotropin.html
Solubility
10 mM in DMSO
Smiles
[Thyrotropin]
References & Citations
[1]Wolf G. The regulation of the thyroid-stimulating hormone of the anterior pituitary gland by thyroid hormone and by 9-cis-retinoic acid. Nutr Rev. 2002 Nov;60(11):374-7. |[2]Vassart G, et al. The thyrotropin receptor and the regulation of thyrocyte function and growth. Endocr Rev. 1992 Aug;13(3):596-611.|[3]Kim SM, et al. Thyrotropin, Hyperthyroidism, and Bone Mass[J]. J Clin Endocrinol Metab. 2021 Nov 19;106(12):e4809-e4821.|[4]Chandrasekar A, et al. Regulation of Thyroid Hormone Gatekeepers by Thyrotropin in Tanycytes[J]. Thyroid. 2024 Feb;34(2):261-273.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-107916/Thyrotropin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-107916/Thyrotropin-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
9002-71-5
Available Sizes
Curated Selection
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