Ramentaceone

Ramentaceone (7-Methyljuglon), a naphthoquinone that can be isolated from Drosera sp., inhibits PI3K activity. Ramentaceone (7-Methyljuglon) reduces the expression of the PI3K protein and inhibits the phosphorylation of the Akt protein in breast cancer cells. Ramentaceone (7-Methyljuglon) induces apoptosis[1].

Product Specifications

CAS Number

[14787-38-3]

Product Name Alternative

7-Methyljuglon

UNSPSC

12352005

Hazard Statement

H301-H315-H319

Target

Apoptosis; PI3K

Type

Natural Products

Related Pathways

Apoptosis; PI3K/Akt/mTOR

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ramentaceone.html

Solubility

10 mM in DMSO

Smiles

O=C1C=CC(C2=C1C=C(C)C=C2O)=O

Molecular Formula

C11H8O3

Molecular Weight

188.18

Precautions

P264-P270-P280-P302+P352-P330-P362+P364-P405-P501

References & Citations

[1]Anna Kawiak, et al. Ramentaceone, a Naphthoquinone Derived from Drosera sp., Induces Apoptosis by Suppressing PI3K/Akt Signaling in Breast Cancer Cells. PLoS One. 2016 Feb 3;11 (2) :e0147718.