SKL2001
SKL2001 is an agonist of the Wnt/β-catenin pathway, with anti-cancer activity. SKL2001 stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction[1].
Product Specifications
CAS Number
909089-13-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Wnt; β-catenin
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SKL2001.html
Concentration
10mM
Purity
99.68
Solubility
DMSO : ≥ 96.66 mg/mL
Smiles
O=C(C1=NOC(C2=CC=CO2)=C1)NCCCN3C=CN=C3
Molecular Formula
C14H14N4O3
Molecular Weight
286.29
Precautions
H302, H315, H319, H335
References & Citations
[1]Gwak J, et al. Small molecule-based disruption of the Axin/β-catenin protein complex regulates mesenchymal stem cell differentiation. ell Res. 2012 Jan;22 (1) :237-47.|[2]Ohashi W, et al. SKL2001 suppresses colon cancer spheroid growth through regulation of the E-cadherin/β-Catenin complex. Biochem Biophys Res Commun. 2017 Nov 25;493 (3) :1342-1348.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![ASS1 Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI4G9]](https://cdn.genprice.uk/products/937/68dd1b81061270361ea1e9f6/imageurl/ta809138am.webp)
TA809138AM 100 µL
ASS1 Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI4G9]
Sign In for Pricing
View Details 
BNC551137-100 1x 100 µL
ZAP70 (ZAP70/528 + 2F3.2), CF555 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC940793-100 1x 100 µL
Phosphotyrosine (PY793), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 