Vipoglanstat

Vipoglanstat (BI 1029539), a carboxamide, is a potent and selective, non-peptide and orally active small molecular inhibitor of human prostaglandin E synthase 1 (mPGES-1) . Vipoglanstat also has anti-inflammatory activity[1][2].

Product Specifications

CAS Number

[1360622-01-0]

Product Name Alternative

BI 1029539; GS-248; OX-MPI

UNSPSC

12352005

Target

PGE synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/vipoglanstat.html

Purity

99.86

Solubility

DMSO : 150 mg/mL (ultrasonic)

Smiles

CN1C2=CC(OCC(F)F)=C(C(N[C@@H]3CC[C@H](CC3)C(F)(F)F)=O)C=C2N=C1NC4=C(C(CNC(C(C)(C)C)=O)=CC=C4Cl)Cl

Molecular Formula

C30H34Cl2F5N5O3

Molecular Weight

678.52

References & Citations

[1]International Nonproprietary Names for Pharmaceutical Substances (INN) . WHO Drug Information, Vol. 36, No. 2, 2022. |[2]Malarvizhi Gurusamy, et al. Inhibition of microsomal prostaglandin E synthase-1 ameliorates acute lung injury in mice.|[3]Yan-Yu Zhang, et al. Microsomal prostaglandin E 2 synthase-1 and its inhibitors: Molecular mechanisms and therapeutic significance. Pharmacol Res. 2022 Jan;175:105977.