GW-405833
GW-405833 (L768242) is a potent, selective cannabinoid receptor 2 (CB2) agonist. GW405833 has EC50 and Ki values of 0.65 nM and 3.92 nM for CB2, and EC50 and Ki values of 16.1 μM and 4772 nM for CB1. GW-405833 also exhibits non-competitive CB1 antagonist, exerting its analgesic and and anti-inflammatory effect through a CB1 receptor (rather than CB2) dependent mechanism. GW-405833 can significantly inhibit the production of cAMP stimulated by Forskolin (HY-15371) . GW405833 inhibits glycolysis by down-regulating HIF-1α, thereby alleviating acute liver failure (ALF) [1][2][3][4][5].
Product Specifications
CAS Number
[180002-83-9]
Product Name Alternative
L768242
UNSPSC
12352005
Hazard Statement
H301, H413
Target
Cannabinoid Receptor; Endogenous Metabolite; HIF/HIF Prolyl-Hydroxylase; Interleukin Related; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gw-405833.html
Concentration
10mM
Purity
98.91
Solubility
DMSO : 116.67 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=C(C(Cl)=CC=C1)Cl)N2C3=C(C=C(OC)C=C3)C(CCN4CCOCC4)=C2C
Molecular Formula
C23H24Cl2N2O3
Molecular Weight
447.35
Precautions
H301, H413
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CB1; CB2; HIF-1α; IL-1
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items