Etoricoxib (Standard)

Etoricoxib (Standard) is the analytical standard of Etoricoxib. This product is intended for research and analytical applications. Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.

Product Specifications

CAS Number

[202409-33-4]

Product Name Alternative

MK-0663 (Standard) ; L-791456 (Standard)

UNSPSC

12352005

Hazard Statement

H302, H310

Target

COX; Reference Standards

Type

Reference Standards

Related Pathways

Immunology/Inflammation; Others

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/etoricoxib-standard.html

Purity

99.92

Smiles

O=S(C1=CC=C(C2=CC(Cl)=CN=C2C3=CC=C(C)N=C3)C=C1)(C)=O

Molecular Formula

C18H15ClN2O2S

Molecular Weight

358.84

Precautions

H302, H310

References & Citations

[1]Riendeau D, et al.Etoricoxib (MK-0663) : preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2. J Pharmacol Exp Ther. 2001 Feb;296 (2) :558-66.|[2]Kunak CS, et al. The Effect of Etoricoxib on Hepatic Ischemia-Reperfusion Injury in Rats. Oxid Med Cell Longev. 2015;2015:598162.|[3]Tanwar L, et al. Anti-proliferative and apoptotic effects of etoricoxib, a selective COX-2 inhibitor, on 1,2-dimethylhydrazine dihydrochloride-induced colon carcinogenesis. Asian Pac J Cancer Prev. 2010;11 (5) :1329-33.