Oosporein

Oosporein is a microbial metabolite and a red crystalline toxin produced by various fungi. Oosporein can promote the reproduction of fungi in host bodies by inhibiting insect immunity, and possesses multiple activities such as antibacterial, antiviral (HSV), and insecticidal effects. Oosporein can inhibit plant growth. In addition, Oosporein can also induce apoptosis, cell membrane damage, oxidative stress, and mitochondrial damage. Oosporein has certain antitumor activity[1][2][3][4][5].

Product Specifications

CAS Number

[475-54-7]

UNSPSC

12352211

Target

Apoptosis; Bacterial; Caspase; Endogenous Metabolite; Fungal; HSV; Parasite; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/oosporein.html

Purity

99.16

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O=C(C(C)=C1O)C(O)=C(C2=C(O)C(C(C)=C(O)C2=O)=O)C1=O

Molecular Formula

C14H10O8

Molecular Weight

306.22

References & Citations

[1]Cole RJ, et al. Toxic effects of oosporein from Chaetomium trilaterale. J Agric Food Chem. 1974;22 (3) :517-520.|[2]Taniguchi M, et al. Antimicrobial and Respirationinhibitory Activities of Oosporein. Agricultural and biological chemistry, 1984, 48 (4) : 1065-1067.|[3]Feng P, et al. C. Fungal biosynthesis of the bibenzoquinone oosporein to evade insect immunity. Proc Natl Acad Sci U S A. 2015 Sep 8;112 (36) :11365-70.|[4]Mao B Z, et al. Separation and determination of the bioactivity of oosporein from Chaetomium cupreum. African Journal of Biotechnology, 2010, 9 (36) .|[5]Ramesha A, et al. Cytotoxic effects of oosporein isolated from endophytic fungus Cochliobolus kusanoi. Front Microbiol. 2015 Sep 1;6:870.