Estradiol 3-sulfamate

Estradiol 3-sulfamate (BLE 00084; E2MATE; ES-J 995) is a potent, long-acting, and orally active steroid sulfatase inhibitor; inhibits estrone sulfatase with an IC50 of 251 nM and a Ki of 133 nM.

Product Specifications

CAS Number

[172377-52-5]

Product Name Alternative

BLE 00084; E2MATE; ES-J 995

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Steroid Sulfatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Estradiol_3-sulfamate.html

Purity

99.87

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

C[C@@]1([C@H]2O)[C@](CC2)([H])[C@@](CCC3=C4C=CC(OS(N)(=O)=O)=C3)([H])[C@]4([H])CC1

Molecular Formula

C18H25NO4S

Molecular Weight

351.46

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Numazawa M, et al. Inhibition of estrone sulfatase by aromatase inhibitor-based estrogen 3-sulfamates. Steroids. 2006 May;71 (5) :371-9.|[2]Pohl O, et al. Synergistic effects of E2MATE and norethindrone acetate on steroid sulfatase inhibition: a randomized phase I proof-of-principle clinical study in women of reproductive age. Reprod Sci. 2014 Oct;21 (10) :1256-65.