NF279

NF279 is a potent selective and reversible P2X1 receptor antagonist, with an IC50 of 19 nM. NF279 displays good selectivity over P2X2, P2X3 (IC50=1.62 μM), P2X4 (IC50>300 μM) . NF279 is a dual HIV-1 coreceptor inhibitor that interferes with the functional engagement of CCR5 and CXCR4 by Env[1][2].

Product Specifications

CAS Number

[202983-32-2]

UNSPSC

12352005

Target

HIV; P2X Receptor

Type

Reference compound

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/nf279.html

Purity

98.5

Solubility

H2O : 25 mg/mL (ultrasonic; warming) |DMSO : 14.5 mg/mL (ultrasonic; warming)

Smiles

O=C(NC1=CC=C(C=C1)C(NC2=CC=C(C=C2)C(NC3=CC=C(S(=O)(O[Na])=O)C4=CC(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C34)=O)=O)NC5=CC=C(C=C5)C(NC6=CC=C(C=C6)C(NC7=CC=C(S(=O)(O[Na])=O)C8=CC(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C78)=O)=O

Molecular Formula

C49H30N6Na6O23S6

Molecular Weight

1401.12

References & Citations

[1]Rettinger J, Schmalzing G, Damer S, Müller G, Nickel P, Lambrecht G. The suramin analogue NF279 is a novel and potent antagonist selective for the P2X (1) receptor. Neuropharmacology. 2000;39 (11) :2044-2053.|[2]Giroud C, et al. P2X1 Receptor Antagonists Inhibit HIV-1 Fusion by Blocking Virus-Coreceptor Interactions. J Virol. 2015;89 (18) :9368-9382.