NF279
NF279 is a potent selective and reversible P2X1 receptor antagonist, with an IC50 of 19 nM. NF279 displays good selectivity over P2X2, P2X3 (IC50=1.62 μM), P2X4 (IC50>300 μM) . NF279 is a dual HIV-1 coreceptor inhibitor that interferes with the functional engagement of CCR5 and CXCR4 by Env[1][2].
Product Specifications
CAS Number
202983-32-2
UNSPSC
12352005
Target
HIV; P2X Receptor
Type
Reference compound
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/nf279.html
Purity
98.5
Solubility
H2O : 25 mg/mL (ultrasonic; warming) |DMSO : 14.5 mg/mL (ultrasonic; warming)
Smiles
O=C(NC1=CC=C(C=C1)C(NC2=CC=C(C=C2)C(NC3=CC=C(S(=O)(O[Na])=O)C4=CC(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C34)=O)=O)NC5=CC=C(C=C5)C(NC6=CC=C(C=C6)C(NC7=CC=C(S(=O)(O[Na])=O)C8=CC(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C78)=O)=O
Molecular Formula
C49H30N6Na6O23S6
Molecular Weight
1401.12
References & Citations
[1]Rettinger J, Schmalzing G, Damer S, Müller G, Nickel P, Lambrecht G. The suramin analogue NF279 is a novel and potent antagonist selective for the P2X (1) receptor. Neuropharmacology. 2000;39 (11) :2044-2053.|[2]Giroud C, et al. P2X1 Receptor Antagonists Inhibit HIV-1 Fusion by Blocking Virus-Coreceptor Interactions. J Virol. 2015;89 (18) :9368-9382.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1; P2X1 Receptor
Available Sizes
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