Endo-β-N-acetylglucosaminidase D
Endo-β-N-acetylglucosaminidase D (Endo D), isolated from Streptococcus pneumoniae. Endo-β-N-acetylglucosaminidase D hydrolyzes Fc N-glycan of intact IgG antibodies after sequential removal of the sialic acid, galactose, and internal GlcNAc residues in the N-glycan. Endo-β-N-acetylglucosaminidase D possesses transglycosylation activity with sugar oxazoline as the donor substrate[1].
Product Specifications
CAS Number
37278-88-9
Product Name Alternative
Endo D
UNSPSC
12352204
Target
Glycosidase
Type
Enzyme
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/endo-β-n-acetylglucosaminidase-d.html
Solubility
10 mM in DMSO
Smiles
[Endo-b-N-acetylglucosaminidaseD]
References & Citations
[1]Shu-Quan Fan, et al. Remarkable Transglycosylation Activity of Glycosynthase Mutants of Endo-D, an Endo-β-N-acetylglucosaminidase from Streptococcus pneumoniae. J Biol Chem. 2012 Mar 30; 287 (14) : 11272–11281.
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20°C for 2 years
Scientific Category
Enzyme
Clinical Information
No Development Reported
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