Endo-β-N-acetylglucosaminidase D

Endo-β-N-acetylglucosaminidase D (Endo D), isolated from Streptococcus pneumoniae. Endo-β-N-acetylglucosaminidase D hydrolyzes Fc N-glycan of intact IgG antibodies after sequential removal of the sialic acid, galactose, and internal GlcNAc residues in the N-glycan. Endo-β-N-acetylglucosaminidase D possesses transglycosylation activity with sugar oxazoline as the donor substrate[1].

Product Specifications

CAS Number

[37278-88-9]

Product Name Alternative

Endo D

UNSPSC

12352204

Target

Glycosidase

Type

Enzyme

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/endo-β-n-acetylglucosaminidase-d.html

Solubility

10 mM in DMSO

Smiles

[Endo-b-N-acetylglucosaminidaseD]

References & Citations

[1]Shu-Quan Fan, et al. Remarkable Transglycosylation Activity of Glycosynthase Mutants of Endo-D, an Endo-β-N-acetylglucosaminidase from Streptococcus pneumoniae. J Biol Chem. 2012 Mar 30; 287 (14) : 11272–11281.