Fosinopril (sodium)

Fosinopril Sodium is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.

Product Specifications

CAS Number

[88889-14-9]

Product Name Alternative

SQ28555

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Angiotensin-converting Enzyme (ACE) ; Apoptosis

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Fosinopril-sodium.html

Purity

99.20

Solubility

H2O : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O[Na])[C@H]1N(C(C[P@@](CCCCC2=CC=CC=C2)(O[C@H](OC(CC)=O)C(C)C)=O)=O)C[C@H](C3CCCCC3)C1

Molecular Formula

C30H45NNaO7P

Molecular Weight

585.64

Precautions

H302, H315, H319, H335

References & Citations

[1]Ondetti, M.A., Structural relationships of angiotensin converting-enzyme inhibitors to pharmacologic activity. Circulation, 1988. 77 (6 Pt 2) : p. I74-8.|[2]Piepho, R.W., Overview of the angiotensin-converting-enzyme inhibitors. Am J Health Syst Pharm, 2000. 57 Suppl 1: p. S3-7.|[3]Sharma, S., et al., The hemodynamic effects of long-term ACE inhibition with fosinopril in patients with heart failure. Fosinopril Hemodynamics Study Group. Am J Ther, 1999. 6 (4) : p. 181-9.