H-Trp-Phe-OH

H-Trp-Phe-OH is a dipeptide consisting of tryptophan and phenylalanine (Trp-Phe) . H-Trp-Phe-OH is also an antihypertensive peptide with inhibitory activity on angiotensin-converting enzyme (ACE), dose-dependently increases NO levels, and decreases endothelin-1 (ET-1) levels. H-Trp-Phe-OH (2 mg/kg; subcutaneous injection; 6 injections over 3 days) causes an increase in ovarian weight in female mice[1][2].

Product Specifications

CAS Number

[6686-02-8]

Product Name Alternative

Trp-Phe

UNSPSC

12352209

Target

Angiotensin-converting Enzyme (ACE)

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/h-trp-phe-oh.html

Purity

99.87

Solubility

DMSO : 100 mg/mL

Smiles

OC([C@H](CC1=CC=CC=C1)NC([C@@H](N)CC2=CNC3=CC=CC=C23)=O)=O

Molecular Formula

C20H21N3O3

Molecular Weight

351.40

References & Citations

[1]Zhao YQ, et al. Eight antihypertensive peptides from the protein hydrolysate of Antarctic krill (Euphausia superba) : Isolation, identification, and activity evaluation on human umbilical vein endothelial cells (HUVECs) . Food Res Int. 2019 Jul;121:197-204.|[2]Pitkow et al. Pharmacological effect of dipeptides on ovarian and uterine weights in immature mice. IRCS Medical Science: Library Compendium (1977), 5 (8), 378.