7-Benzyloxy-4- (trifluoromethyl) coumarin

7-Benzyloxy-4- (trifluoromethyl) coumarin (7-BFC) is a coumarin fluorescent substrate. 7-Benzyloxy-4- (trifluoromethyl) coumarin is a substrate for cDNA-expressed CYP1A2 and CYP3A4 and is metabolized to 7-hydroxy-4-trifluoromethylcoumarin (HFC) . 7-Benzyloxy-4- (trifluoromethyl) coumarin is used for rapid CYP isoform metabolism and inhibition screening studies[1].

Product Specifications

CAS Number

[220001-53-6]

Product Name Alternative

7-BFC

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/7-benzyloxy-4-trifluoromethyl-coumarin.html

Purity

98.76

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

C1=CC=C(C=C1)COC2=CC3=C(C=C2)C(=CC(=O)O3)C(F)(F)F

Molecular Formula

C17H11F3O3

Molecular Weight

320.27

Precautions

H302, H312, H332

References & Citations

[1]A B Renwick, et al. Metabolism of 7-benzyloxy-4-trifluoromethyl-coumarin by human hepatic cytochrome P450 isoforms. Xenobiotica. 2000 Oct;30 (10) :955-69.