Fabomotizole

Fabomotizole (CM346) is an insecticide with anxiolytic, antianxiety, and neuroprotective activities and a substrate of p-glycoprotein. Fabomotizole inhibits the ST-segment depression induced by isoproterenol in a rat model of acute subendocardial ischemia. Fabomotizole also inhibits Giardia lamblia and has the potential to inhibit giardiasis. Fabomotizole also targets Sigma1R, NRH:quinone reductase 2 (NQO2), and MAO-A to exert anxiolytic effects[1][2][3].

Product Specifications

CAS Number

[173352-21-1]

Product Name Alternative

CM346

UNSPSC

12352005

Hazard Statement

H302

Target

Monoamine Oxidase; Parasite; P-glycoprotein; Sigma Receptor

Type

Reference compound

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Infection; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Fabomotizole.html

Purity

98.31

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCOC1=CC=C2C(N=C(SCCN3CCOCC3)N2)=C1

Molecular Formula

C15H21N3O2S

Molecular Weight

307.41

Precautions

H302

References & Citations

[1]Tsorin IB, et al. Anti-Ischemic Activity of Fabomotizole Hydrochloride under Conditions of Endothelial Dysfunction. Bull Exp Biol Med. 2019 Sep;167 (5) :634-636. |[2]Pérez-Villanueva J, et al. The giardicidal activity of lobendazole, fabomotizole, tenatoprazole and ipriflavone: A ligand-based virtual screening and in vitro study. Eur J Med Chem. 2021 Feb 5;211:113110. |[3]Chernykh I V, et al. Study of fabomotizole belonging to p-glycoprotein substrates[J]. IP Pavlov Russian Medical Biological Herald, 2017, 25 (4) : 538-550.|[4]Voronin MV, Vakhitova YV, Tsypysheva IP, Tsypyshev DO, Rybina IV, Kurbanov RD, Abramova EV, Seredenin SB. Involvement of Chaperone Sigma1R in the Anxiolytic Effect of Fabomotizole. Int J Mol Sci. 2021 May 21;22 (11) :5455.