[10]-Shogaol

[10]-Shogaol is an orally active antioxidant. [10]-Shogaol can be extracted from ginger (Zingiber officinale) . [10]-Shogaol1 inhibits COX-2 with an IC50 value of 7.5 μM. [10]-Shogaol inhibits the production of proinflammatory cytokines (IL-1β, IL-6) . [10]-Shogaol inhibits NF-κB phosphorylation. [10]-Shogaol has anti-inflammatory effects. [10]-Shogaol has anticancer effects against Docetaxel (HY-B0011) -resistant prostate cancer. [10]-Shogaol exhibits larvicidal activity against L5 larvae of Angiostrongylus cantonensis[1][2][3][4][5].

Product Specifications

CAS Number

[36752-54-2]

UNSPSC

12352005

Hazard Statement

H302

Target

COX; Interleukin Related; NF-κB; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Immunology/Inflammation; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/10-shogaol.html

Purity

99.78

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCCCCCCCC/C=C/C(CCC1=CC=C(O)C(OC)=C1)=O

Molecular Formula

C21H32O3

Molecular Weight

332.48

Precautions

H302

References & Citations

[1]Chen CY, et al. 10-Shogaol, an antioxidant from Zingiber officinale for skin cell proliferation and migration enhancer. Int J Mol Sci. 2012;13 (2) :1762-77.|[2]van Breemen RB, et al. Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale) . Fitoterapia. 2011 Jan;82 (1) :38-43.|[3]Liu CM, et al. Ginger Phytochemicals Inhibit Cell Growth and Modulate Drug Resistance Factors in Docetaxel Resistant Prostate Cancer Cell. Molecules. 2017 Sep 5;22 (9) . pii: E1477.