JNJ-10258859
JNJ-10258859 is a potent and selective phosphodiesterase type 5 inhibitor, with a Ki of 0.23 nM. JNJ-10258859 can be used for erectile dysfunction research[1].
Product Specifications
CAS Number
374927-03-4
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/jnj-10258859.html
Smiles
O=C1C2=C(NC3=C1C=CC=C3)[C@H](N(C2)C4=NC=C(C=N4)C5=CC=C(C=C5)OC)C6=CC=C7OCCC7=C6
Molecular Formula
C30H24N4O3
Molecular Weight
488.54
References & Citations
[1]Qiu Y, et al. Characterization of a novel phosphodiesterase type 5 inhibitor: JNJ-10258859. Eur J Pharmacol. 2003 Jul 4;472 (1-2) :73-80.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE1; PDE2; PDE3; PDE4; PDE5
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