Teriflunomide
Teriflunomide is the active metabolite of leflunomide, an approved therapy for rheumatoid arthritis. It inhibits pyrimidine synthesis and therefore potently decreases T cell and B cell proliferation.
Product Specifications
CAS Number
[163451-81-8]
Product Name Alternative
A77 1726
UNSPSC
12352005
Hazard Statement
H302
Target
Drug Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Teriflunomide.html
Purity
99.92
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
C/C(O)=C(C(NC1=CC=C(C=C1)C(F)(F)F)=O)\C#N
Molecular Formula
C12H9F3N2O2
Molecular Weight
270.21
Precautions
H302
References & Citations
[1]Oh J, et al. An update of teriflunomide for treatment of multiple sclerosis. Ther Clin Risk Manag. 2013;9:177-90.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
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