NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal)
Product Specifications
UNSPSC Description
NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) (compound 40), a macrocyclic analogue of Ape13, is a potent APJ agonist (Ki=5.7 nM). NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) exhibits a favorable Gα12-biased signaling and an increased in vivo half-life[1].
Target Antigen
Apelin Receptor (APJ)
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/nh2-c-x-r-l-s-x-k-g-p-d-2nal.html
Solubility
10 mM in DMSO
Smiles
N[C@@H]1C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N2CCC[C@H]2C(N[C@H](CC3=CC=C4C=CC=CC4=C3)C(O)=O)=O)=O)=O)CCCCN)=O)C/C=C\C1)=O)CO)=O)CC(C)C)=O)CCCNC(N)=N)=O
Molecular Weight
1020.18
References & Citations
[1]Tran K, et, al. Size-Reduced Macrocyclic Analogues of [Pyr 1]-apelin-13 Showing Negative Gα 12 Bias Still Produce Prolonged Cardiac Effects. J Med Chem. 2022 Jan 13;65(1):531-551.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P3347/NH2-c-X-R-L-S-X-K-G-P-D-2Nal-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P3347/
Clinical Information
No Development Reported
CAS Number
2891469-81-9
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
