Z57346765

Z57346765 is a PGK1-specific inhibitor that reduces the activity of metabolic enzymes in PGK1 glycolysis and inhibits PGK1-dependent cell proliferation. Z57346765 exerts inhibitory effects against clear cell renal cell carcinoma (KIRC) [1].

Product Specifications

CAS Number

[1016340-64-9]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Phosphoglycerate Kinase (PGK)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/z57346765.html

Purity

99.59

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OCCNC1=C2C=CC=CC2=NC(NC3=CC=C(C)C=C3)=N1

Molecular Formula

C17H18N4O

Molecular Weight

294.36

Precautions

H315, H319, H335

References & Citations

[1]He Y, et al. Novel inhibitors targeting the PGK1 metabolic enzyme in glycolysis exhibit effective antitumor activity against kidney renal clear cell carcinoma in vitro and in vivo. Eur J Med Chem. 2024 Mar 5;267:116209.