Z57346765
Z57346765 is a PGK1-specific inhibitor that reduces the activity of metabolic enzymes in PGK1 glycolysis and inhibits PGK1-dependent cell proliferation. Z57346765 exerts inhibitory effects against clear cell renal cell carcinoma (KIRC) [1].
Product Specifications
CAS Number
[1016340-64-9]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Phosphoglycerate Kinase (PGK)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/z57346765.html
Purity
99.59
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OCCNC1=C2C=CC=CC2=NC(NC3=CC=C(C)C=C3)=N1
Molecular Formula
C17H18N4O
Molecular Weight
294.36
Precautions
H315, H319, H335
References & Citations
[1]He Y, et al. Novel inhibitors targeting the PGK1 metabolic enzyme in glycolysis exhibit effective antitumor activity against kidney renal clear cell carcinoma in vitro and in vivo. Eur J Med Chem. 2024 Mar 5;267:116209.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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