Nalidixic acid

Nalidixic acid, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria[1].

Product Specifications

CAS Number

[389-08-2]

UNSPSC

12352005

Hazard Statement

H302, H361

Target

Antibiotic; Bacterial; Topoisomerase

Type

Natural Products

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/nalidixic-acid.html

Concentration

10mM

Purity

99.97

Solubility

0.1 M NaOH : 10 mg/mL (ultrasonic) |DMSO : 6 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=CN(CC)C2=C(C=CC(C)=N2)C1=O)O

Molecular Formula

C12H12N2O3

Molecular Weight

232.24

Precautions

H302, H361

References & Citations

[1]antibiotic, DNA gyrase, susceptible bacteria, Escherichia coli, Klebsiella pneuiiioniae, Aerobacter aeroyenes, Proteus spp, Salmonella spp.|[2]Anna Fàbrega, et al. Mechanism of Action of and Resistance to Quinolones. Microb Biotechnol