Nalidixic acid
Product Specifications
UNSPSC Description
Nalidixic acid, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria[1].
Target Antigen
Antibiotic; Bacterial; Topoisomerase
Type
Natural Products
Related Pathways
Anti-infection;Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/nalidixic-acid.html
Purity
99.97
Solubility
0.1 M NaOH : 10 mg/mL (ultrasonic)|DMSO : 6 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C(C1=CN(CC)C2=C(C=CC(C)=N2)C1=O)O
Molecular Weight
232.24
References & Citations
[1]antibiotic, DNA gyrase, susceptible bacteria, Escherichia coli, Klebsiella pneuiiioniae, Aerobacter aeroyenes, Proteus spp, Salmonella spp.|[2]Anna Fàbrega, et al. Mechanism of Action of and Resistance to Quinolones. Microb Biotechnol
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-B0398/Nalidixic-acid-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-B0398/Nalidixic-acid-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
389-08-2
Available Sizes
Curated Selection
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