Alendronate (sodium hydrate)

Alendronate (sodium hydrate) is a farnesyl diphosphate synthase inhibitor with IC50 of 460 nM.

Product Specifications

CAS Number

[121268-17-5]

Product Name Alternative

Alendronate; MK 217; G-704650 Adronat

UNSPSC

12352211

Hazard Statement

H302

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Alendronate-sodium-hydrate.html

Purity

99.6

Solubility

H2O : ≥ 28.57 mg/mL

Smiles

OP(C(O)(CCCN)P(O)(O[Na])=O)(O)=O.[3H2O]

Molecular Formula

C4H18NNaO10P2

Molecular Weight

325.12

Precautions

H302

References & Citations

[1]Fisher JE, et al. Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. Proc Natl Acad Sci U S A. 1999 Jan 5;96 (1) :133-8|[2]Bergstrom JD, et al. Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase. Arch Biochem Biophys. 2000 Jan 1;373 (1) :231-41.|[3]Keller RK, et al. Mechanism of aminobisphosphonate action: characterization of alendronate inhibition of the isoprenoid pathway. Biochem Biophys Res Commun. 1999 Dec 20;266 (2) :560-3.|[4]Elliott SN, et al. Alendronate induces gastric injury and delays ulcer healing in rodents. Life Sci. 1998;62 (1) :77-91.|[5]Stearns ME, et al. Effects of alendronate and taxol on PC-3 ML cell bone metastases in SCID mice. Invasion Metastasis. 1996;16 (3) :116-31.