Devimistat
Devimistat is a mitochondrial metabolism inhibitor. Devimistat is a lipoic acid antagonist that abrogates mitochondrial energy metabolism to induce apoptosis in various cancer cells[1].
Product Specifications
CAS Number
[95809-78-2]
UNSPSC
12352005
Hazard Statement
H410
Target
Apoptosis; Mitochondrial Metabolism
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CPI-613.html
Concentration
10mM
Purity
99.59
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)CCCCC(SCC1=CC=CC=C1)CCSCC2=CC=CC=C2
Molecular Formula
C22H28O2S2
Molecular Weight
388.59
Precautions
H410
References & Citations
[1]Sakuratani T, et al. Downregulation of ARID1A in gastric cancer cells: a putative protective molecular mechanism against the Harakiri-mediated apoptosis pathway. Virchows Arch. 2021;478 (3) :401-411.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
Curated Selection
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