IR-58
IR-58, a mitochondria-targeting near-infrared (NIR) fluorophore, is an autophagy enhancer. IR-58 kills tumour cells and induces apoptosis via inducing excessive autophagy, which is mediated through the reactive oxygen species (ROS) -Akt-mTOR pathway[1].
Product Specifications
CAS Number
2374274-85-6
UNSPSC
12171500
Target
Apoptosis; Autophagy
Type
Dye Reagents
Related Pathways
Apoptosis; Autophagy
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ir-58.html
Solubility
10 mM in DMSO
Smiles
O=C(CNC(CCCCCCCCCCN1C2=C(C(C)(C)/C1=C/C=C3C(Cl)=C(CCC/3)/C=C/C4=[N+](CCCCCCCCCCC(NCC(OC)=O)=O)C5=C(C4(C)C)C=CC=C5)C=CC=C2)=O)OC.[Br-]
Molecular Formula
C58H82BrClN4O6
Molecular Weight
1046.65
References & Citations
[1]Yinghui Huang, et al. Identification of a fluorescent small-molecule enhancer for therapeutic autophagy in colorectal cancer by targeting mitochondrial protein translocase TIM44. Gut. 2018 Feb;67 (2) :307-319.
Shipping Conditions
Room temperature
Scientific Category
Dye Reagents
Clinical Information
No Development Reported
Frequently Asked Questions
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