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Sanguinarine

Sanguinarine (Sanguinarin), a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS) . Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.

Product Specifications

CAS Number

2447-54-3

Product Name Alternative

Sanguinarin; Sanguinarium; Pseudochelerythrine

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Apoptosis; Autophagy

Type

Natural Products

Related Pathways

Apoptosis; Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Sanguinarine.html

Solubility

10 mM in DMSO

Smiles

C[N+]1=CC2=C3C(OCO3)=CC=C2C(C=CC4=C5)=C1C4=CC6=C5OCO6

Molecular Formula

C20H14NO4

Molecular Weight

332.33

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Wang Y, Noninvasive bioluminescence imaging of the dynamics of sanguinarine induced apoptosis via activation of reactive oxygen species. Oncotarget. 2016 Apr 19;7 (16) :22355-67.

Shipping Conditions

Room temperature

Scientific Category

Natural Products

Clinical Information

Launched

Citation 01

Adv Sci (Weinh) . 2024 Jul 5:e2403451.|Comp Biochem Physiol C Toxicol Pharmacol. 28 October 2021, 109228.|Fishes. 2022, 7 (5), 229.|Pestic Biochem Physiol. 2022 Nov:188:105259.|PLoS Pathog. 2023 Dec 7;19 (12) :e1011796.|Toxicol Lett. 2021 Oct 10:350:71-80.|Am J Chin Med. 2025;53 (5) :1545-1571.|bioRxiv. 2024 Feb 5.|Brain Behav Immun Health. 2022 Oct 29:26:100546.|Oncogene. 2025 May;44 (16) :1078-1092.|Phytother Res. 2023 Oct;37 (10) :4771-4790.|Planta Med. 2024 Jun;90 (7-08) :523-533.|Research Square Print. 2022 Jun.

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