Cholesterol
Product Specifications
UNSPSC Description
Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins[1][2]. Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist[3].
Target Antigen
Bacterial; Endogenous Metabolite; Estrogen Receptor/ERR; Liposome
Type
Natural Products
Related Pathways
Anti-infection;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Field of Research
Metabolic Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Cholesterol.html
Purity
99.94
Solubility
DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C)|Ethanol : 20 mg/mL (ultrasonic)
Smiles
O[C@H](C1)CC[C@@]2(C)C1=CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@@H](CCCC(C)C)C
Molecular Weight
386.65
References & Citations
[1]Casaburi I, et al. Cholesterol as an Endogenous ERRα Agonist: A New Perspective to Cancer Treatment. Front Endocrinol (Lausanne). 2018 Sep 11;9:525.|[2]Dietschy JM, et al. Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal. J Lipid Res. 2004 Aug;45(8):1375-97.|[3]Fukui K, et al. Effect of Cholesterol Reduction on Receptor Signaling in Neurons. J Biol Chem. 2015 Sep 14.|[4]Puskás LG, et al. Cholesterol diet-induced hyperlipidemia influences gene expression pattern of rat hearts: a DNA microarray study. FEBS Lett. 2004 Mar 26;562(1-3):99-104.|[5]Onody A, et al. Hyperlipidemia induced by a cholesterol-rich diet leads to enhanced peroxynitrite formation in rat hearts. Cardiovasc Res. 2003 Jun 1;58(3):663-70.|[6]Baumer Y, et al. Hyperlipidemia-induced cholesterol crystal production by endothelial cells promotes atherogenesis. Nat Commun. 2017 Oct 24;8(1):1129.|[7]Finking G, et al. Nikolaj Nikolajewitsch Anitschkow (1885-1964) established the cholesterol-fed rabbit as a model for atherosclerosis research. Atherosclerosis. 1997 Nov;135(1):1-7.|[8]Fan J, et al. Use of Rabbit Models to Study Atherosclerosis. Methods Mol Biol. 2022;2419:413-431.ACS Appl Mater Interfaces. 2024 Aug 5.|Adv Sci (Weinh). 2024 Aug 9:e2402329.|Adv Sci (Weinh). 2024 Jul 1:e2403640.|Antiviral Res. 2022 Dec 15;209:105497.|Biochem Biophys Res Commun. 2020 Feb 19;522(4):862-868.|Cell Death Discov. 2024 May 29;10(1):263.|Cell Metab. 2024 Oct 4:S1550-4131(24)00371-1.|Cell Mol Life Sci. 2024 Jul 6;81(1):289.|Cell Signal. 2024 Sep 16:111419.|EMBO Mol Med. 2024 Jul 19.|Free Radic Biol Med. 2024 Aug 27:S0891-5849(24)00623-3.|Int J Pharm. 2024 Aug 18:124608.|iScience. 2024 Apr 3.|J Nanobiotechnology. 2022 Oct 20;20(1):454.|J Pharm Sci. 2024 May 25:S0022-3549(24)00199-0.|Life Sci Alliance. 2022 Jan 4;5(3):e202101256.|Life Sci. 2023 Apr 18;121698.|Nanomedicine. 2024 Mar 16:102745.|Nat Chem Biol. 2022 Aug 18.|Nat Commun. 2024 Jan 2;15(1):162.|Nat Nanotechnol. 2021 Oct;16(10):1150-1160.|Nature. 2024 Dec 18.|Part Part Syst Charact. 2024 Jun 12.|Patent. US20200376102A1.|Patent. US20200376146A1.|Phytomedicine. 2024 Jan 20, 155299.|Polym Test. 2023 Dec 1, 108292.|Redox Biol. 2023 Jun.|Sci China Life Sci. 2021 May 27;1-21.|SSRN. 2024 Feb 5.|Theranostics. 2021 Jan 1;11(2):841-860.|Vet Microbiol. 2024 Jan, 288, 109948.|Viruses. 2022, 14(3), 514.|Adv Sci (Weinh). 2023 Sep;10(27):e2206878.|Immunity. 2024 May 14;57(5):1087-1104.e7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N0322/Cholesterol-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N0322/Cholesterol-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
57-88-5
Available Sizes
Curated Selection
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