7-Deazaguanine

7-Deazaguanine (Compound 1) is a highly selective, well-tolerated, brain-penetrant DYRK1A inhibitor. 7-Deazaguanine is promising for research of cancers and Down’s syndrome[1].

Product Specifications

CAS Number

[7355-55-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

DYRK

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/7-deazaguanine.html

Purity

99.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C2=C(NC=C2)NC(N)=N1

Molecular Formula

C6H6N4O

Molecular Weight

150.14

Precautions

H302, H315, H319, H335

References & Citations

[1]Lee Walmsley D, et al. Fragment-Derived Selective Inhibitors of Dual-Specificity Kinases DYRK1A and DYRK1B. J Med Chem. 2021 Jul 8;64 (13) :8971-8991.