I-CBP112

I-CBP112, a chemical probe, is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor, that inhibits the CBP/p300 bromodomains, enhances acetylation by p300.

Product Specifications

CAS Number

[1640282-31-0]

UNSPSC

12352005

Hazard Statement

H410

Target

Epigenetic Reader Domain; Histone Acetyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/I-CBP112.html

Purity

98.20

Solubility

1M HCl : 100 mg/mL (ultrasonic; adjust pH to 1 with HCl) |DMSO : ≥ 32 mg/mL

Smiles

COC1=C(OC)C=C(C2=CC(OC[C@H]3CCCN(C)C3)=C(OCCN(C(CC)=O)C4)C4=C2)C=C1

Molecular Formula

C27H36N2O5

Molecular Weight

468.59

Precautions

P273-P391-P501

References & Citations

[1]Zucconi BE, et al. Modulation of p300/CBP Acetylation of Nucleosomes by Bromodomain LigandI-CBP112. Biochemistry. 2016 Jul 12;55 (27) :3727-34.|[2]Picaud S, et al. Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy. Cancer Res. 2015 Dec 1;75 (23) :5106-19.