EGFR T790M/L858R-IN-8
Product Specifications
UNSPSC Description
EGFR T790M/L858R-IN-8 (compound 9) is a potent inhibitor of EGFR, targeting mutant EGFRT790M/L858R with IC50 of 56.8 μM. The anti-proliferative effect of EGFR T790M/L858R-IN-8 on cancer cell lines A549, A431, and NHI-H1975 is not significant[1].
Target Antigen
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-t790m-l858r-in-8.html
Solubility
DMSO : 2 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C(C1=C(O)C2=C(C=CC=C2)NC1=O)NC3=CC(Br)=CC=C3
Molecular Weight
359.17
References & Citations
[1]Bai F, et al. Discovery of novel selective inhibitors for EGFR-T790M/L858R. Bioorg Med Chem Lett. 2012 Feb 1;22(3):1365-70.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-164056/EGFR-T790M-L858R-IN-8-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-164056/EGFR-T790M-L858R-IN-8-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
333419-97-9
Available Sizes
Curated Selection
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