Dehydroandrographolide succinate

Dehydroandrographolide succinate can be extracted from herbal medicine Andrographis paniculata (Burm f) Nees, is widely used in research for viral pneumonia and viral upper respiratory tract infections because of its immunostimulatory, anti-infective and anti-inflammatory effect. Dehydroandrographolide succinate exerts antithrombotic effect. Dehydroandrographolide succinate significantly inhibits the platelet aggregation rate (ED50 = 386.9 mg/kg) by decreasing TXB2 levels. Dehydroandrographolide succinate mitigates muscle astrophy via the Akt/GSK3β and MuRF-1 pathways[1][2][3].

Product Specifications

CAS Number

[786593-06-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Akt; GSK-3; Influenza Virus; Prostaglandin Receptor

Type

Natural Products

Related Pathways

Anti-infection; GPCR/G Protein; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Neuroscience-Neuromodulation

Field of Research

Infection; Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/dehydroandrographolide-succinate.html

Purity

99.88

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(OC[C@]1(C)[C@H](OC(CCC(O)=O)=O)CC[C@@]2(C)[C@H](/C=C/C3=CCOC3=O)C(CC[C@]12[H])=C)CCC(O)=O

Molecular Formula

C28H36O10

Molecular Weight

532.58

Precautions

H302, H315, H319, H335

References & Citations

[1]Chen Q, et al. Pharmacokinetics and tolerance of dehydroandrographolide succinate injection after intravenousadministration in healthy Chinese volunteers. Acta Pharmacol Sin. 2012 Oct;33 (10) :1332-6.|[2]Bowen Yin, et al., The antithrombosis effect of dehydroandrographolide succinate: in vitro and in vivo studies. (2022) . The antithrombosis effect of dehydroandrographolide succinate: in vitro and in vivo studies. Pharmaceutical Biology, 60 (1), 175–184.|[3]Jin, H., et al., (2025) . Dehydroandrographolide succinate attenuates dexamethasone-induced skeletal muscle atrophy by regulating Akt/GSK3β and MuRF-1 pathways. European journal of pharmacology, 990, 177265.