Isosorbide mononitrate

Isosorbide mononitrate (Isosorbide-5-mononitrate) is an orally active nitric acid compound used for angina pectoris by dilating blood vessels and lowering blood pressure. Isosorbide mononitrate increases the viability and proliferation of HUVECs by decreasing Apoptosis and elevated the expressions of vedf, kdrl, pdgfr in zebrafish embryos. Isosorbide mononitrate is promising for research of heart failure and coronary heart disease[1][2][3][4].

Product Specifications

CAS Number

[16051-77-7]

Product Name Alternative

Isosorbide-5-mononitrate

UNSPSC

12352005

Hazard Statement

H228, H361

Target

Apoptosis; Autophagy; Endogenous Metabolite

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Isosorbide-mononitrate.html

Purity

99.95

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

O=[N+]([O-])O[C@H]1[C@](OC[C@@H]2O)([H])[C@]2([H])OC1

Molecular Formula

C6H9NO6

Molecular Weight

191.14

Precautions

H228, H361

References & Citations

[1]Redfield MM, et al. Isosorbide Mononitrate in Heart Failure with Preserved Ejection Fraction. N Engl J Med. 2015 Dec 10;373 (24) :2314-24. |[2]Abshagen UW. Pharmacokinetics of isosorbide mononitrate. Am J Cardiol. 1992 Nov 27;70 (17) :61G-66G. |[3]Pipili-Synetos E, et al. Inhibition of angiogenesis, tumour growth and metastasis by the NO-releasing vasodilators, isosorbide mononitrate and dinitrate. Br J Pharmacol. 1995 Sep;116 (2) :1829-34. |[4]Lv H, et al. Isosorbide mononitrate promotes angiogenesis in embryonic development of zebrafish. Genet Mol Biol. 2020 Jul 24;43 (3) :20190233.