Domagrozumab

Domagrozumab is an anti-myostatin humanized monoclonal antibody with a KD value of 2.6 pM for human myostatin. Domagrozumab induces muscle anabolic activity. Domagrozumab can be used in research of duchenne muscular dystrophy (DMD) [1].

Product Specifications

CAS Number

[1629605-31-7]

Product Name Alternative

PF-06252616

UNSPSC

12352203

Target

TGF-beta/Smad

Type

Inhibitory Antibodies

Related Pathways

Stem Cell/Wnt; TGF-beta/Smad

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/domagrozumab.html

Purity

96.34

Solubility

10 mM in DMSO

Smiles

[Domagrozumab]

Molecular Weight

(143.96 kDa)

References & Citations

[1]St Andre M, et, al. A mouse anti-myostatin antibody increases muscle mass and improves muscle strength and contractility in the mdx mouse model of Duchenne muscular dystrophy and its humanized equivalent, domagrozumab (PF-06252616), increases muscle volume in cynomolgus monkeys. Skelet Muscle. 2017 Nov 9;7 (1) :25.