Oridonin
HSP70 inhibitor & NLRP inflammasome inhibitor
Product Specifications
Background
A potent, covalent inhibitor of the NLRP3 inflammasome with anti-inflammatory activity in various mouse models (1). Inhibits vascular inflammation in vivo (2). Inhibits aberrant AKT activation in human breast cancer cells with hyperactivated PI3K/AKT signaling (3). Inhibits migration, invasion and adhesion of melanoma cells (4). Induces apoptosis in osteosarcoma cells by multiple pathways (5).
Product Name Alternative
7a,20-Epoxy-1a,6b,7,14-tetrahydroxykaur-16-en-15-one; Isodonol
UNSPSC
41116105
Source
Synthetic
Purity
>98% (TLC); NMR (Conforms)
Weight
0.005
Format
White to off-white powder
Solubility
May be dissolved in DMSO (50 mg/ml); or Ethanol (10 mg/ml, warm)
Molecular Formula
C20H28O6
Molecular Weight
364.4
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. He H., et al. (2018) Nat. Commun. 9:2550.
2. Huang W., et al. (2018) Eur. J. Pharmacol. 826:133.
3. Sun B., et al. (2018) Oncotarget 9:23878.
4. Li CY., et al. (2018) Oncol. Lett. 15:1362.
5. Lu Y., et al. (2018) Cell Death Dis. 9:15.
CAS Number
28957-04-2
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