LY302148
LY302148 is a receptor ligand for 5-HT1F. Compared to the Emax of 5-HT, LY302148 behaves as a partial agonist for the 5-HT1F receptor. In the [35S]GTPγS binding assay targeting human 5-HT1F receptors, LY302148 exhibits good potency with an EC50 value of 5.23 nM. LY302148 can be used in the research of migraine[1].
Product Specifications
CAS Number
182564-47-2
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ly302148.html
Smiles
CN1N=CC(CCN2CCC(C3=CNC4=C3C=C(F)C=C4)CC2)=C1
Molecular Formula
C19H23FN4
Molecular Weight
326.41
References & Citations
[1]Wainscott D B, et al. Human 5-HT1F receptor-stimulated [35S] GTPγS binding: correlation with inhibition of guinea pig dural plasma protein extravasation[J]. European journal of pharmacology, 1998, 352 (1) : 117-124.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor
Frequently Asked Questions
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