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LY302148

LY302148 is a receptor ligand for 5-HT1F. Compared to the Emax of 5-HT, LY302148 behaves as a partial agonist for the 5-HT1F receptor. In the [35S]GTPγS binding assay targeting human 5-HT1F receptors, LY302148 exhibits good potency with an EC50 value of 5.23 nM. LY302148 can be used in the research of migraine[1].

Product Specifications

CAS Number

182564-47-2

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ly302148.html

Smiles

CN1N=CC(CCN2CCC(C3=CNC4=C3C=C(F)C=C4)CC2)=C1

Molecular Formula

C19H23FN4

Molecular Weight

326.41

References & Citations

[1]Wainscott D B, et al. Human 5-HT1F receptor-stimulated [35S] GTPγS binding: correlation with inhibition of guinea pig dural plasma protein extravasation[J]. European journal of pharmacology, 1998, 352 (1) : 117-124.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

5-HT1 Receptor

Frequently Asked Questions

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