N-Methylpyrrolidone

N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an orally active organic polar solvent with teratogenicity and toxicity. N-Methylpyrrolidone is low in acute toxicity with a LD50 value of 3914 mg/kg in rats and of 4050 mg/kg in mice. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals[1][2][3][4].

Product Specifications

CAS Number

[872-50-4]

Product Name Alternative

NMP; 1-Methyl-2-pyrrolidinone

UNSPSC

12352200

Hazard Statement

H227, H315, H319, H335, H360

Target

Biochemical Assay Reagents

Type

Biochemical Assay Reagents

Related Pathways

Others

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-methylpyrrolidone.html

Concentration

10mM

Purity

99.99

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1N(C)CCC1

Molecular Formula

C5H9NO

Molecular Weight

99.13

Precautions

H227, H315, H319, H335, H360

References & Citations

[1]Jing Wang, et al. Nitrate stimulation of N-Methylpyrrolidone biodegradation by Paracoccus pantotrophus: Metabolite mechanism and Genomic characterization. Bioresour Technol. 2019 Dec;294:122185.|[2]Claudia Julieta Solís-González, et al. Novel Metabolic Pathway for N-Methylpyrrolidone Degradation in Alicycliphilus sp. Strain BQ1. Appl Environ Microbiol. 2017 Dec 15;84 (1) :e02136-17.|[3]Malek DE, et al. Repeated dose toxicity study (28 days) in rats and mice with N-methylpyrrolidone (NMP) . Drug Chem Toxicol. 1997 Feb-May;20 (1-2) :63-77. |[4]Malley LA, et al. 90-day subchronic toxicity study in rats and mice fed N-methylpyrrolidone (NMP) including neurotoxicity evaluation in rats. Drug Chem Toxicol. 1999 Aug;22 (3) :455-80.