IWP-2 (GMP)

IWP-2 (GMP) is >IWP-2 (HY-13912) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. IWP-2 is an inhibitor of Wnt processing and secretion with an IC50 of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and blocks Wnt ligand palmitoylation[1].

Product Specifications

CAS Number

[686770-61-6]

UNSPSC

12352005

Hazard Statement

H302

Target

Wnt

Type

GMP Small Molecules

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/iwp-2-gmp.html

Purity

99.7

Solubility

DMSO : 2 mg/mL (ultrasonic; warming)

Smiles

O=C(NC1=NC2=CC=C(C)C=C2S1)CSC3=NC(CCS4)=C4C(N3C5=CC=CC=C5)=O

Molecular Formula

C22H18N4O2S3

Molecular Weight

466.60

Precautions

P264-P270-P330-P501

References & Citations

[1]Guan J et al. Chemical reprogramming of human somatic cells to pluripotent stem cells. Nature. 2022;605 (7909) :325-331. |[2]Hamad S, et al. Generation of human induced pluripotent stem cell-derived cardiomyocytes in 2D monolayer and scalable 3D suspension bioreactor cultures with reduced batch-to-batch variations. Theranostics. 2019 Sep 25;9 (24) :7222-7238. |[3]Le MNT, et al. Auto/paracrine factors and early Wnt inhibition promote cardiomyocyte differentiation from human induced pluripotent stem cells at initial low cell density. Sci Rep. 2021 Nov 2;11 (1) :21426. |[4]Taniguchi J, et al. A synthetic DNA-binding inhibitor of SOX2 guides human induced pluripotent stem cells to differentiate into mesoderm. Nucleic Acids Res. 2017 Sep 19;45 (16) :9219-9228. |[5]Lian X, Zhang J, et al. Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions. Nat Protoc. 2013 Jan;8 (1) :162-75.

Shipping Conditions

Blue Ice

Storage Conditions

4°C, sealed storage, away from moisture

Scientific Category

GMP Small Molecules

Clinical Information

No Development Reported

Citation 01

Available Sizes

Curated Selection

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