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GaTx2

GaTx2 is a seletive and a high affinity inhibitor of ClC-2 channels with a voltage-dependent apparent KD of ∼20 pM. GaTx2 is a peptide toxin inhibitor from Leiurus quinquestriatus hebraeus venom. GaTx2 is useful in determining the role and the membrane localization of ClC-2 in specific cell types[1].

Product Specifications

CAS Number

194665-85-5

UNSPSC

12352209

Target

Chloride Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gatx2.html

Purity

98.00

Solubility

10 mM in DMSO

Smiles

O=C1N2[C@](CCC2)([H])C(N[C@H](C(N[C@H](C(N[C@]3([H])C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@]4([H])CSSCC(C(NC(C(NC(C(N[C@@]1([H])CSSC[C@](C(N[C@H](C(N[C@@H](CSSC3)C(N[C@@H](CCC(O)=O)C(N5[C@@H](CCC5)C(N[C@H](C(O)=O)[C@@H](C)CC)=O)=O)=O)=O)C(C)C)=O)([H])NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC4=O)CC(O)=O)=O)CC(N)=O)=O)CC(O)=O)=O)CCCCN)=O)=O)CC(O)=O)=O)CCC(O)=O)=O)NC([C@H](CO)NC([C@@H](N)C(C)C)=O)=O)=O)CCCCN)=O)C)=O)CCCNC(N)=N)=O)C)=O)CCCCN)=O)CCC(N)=O)=O)([H])[C@H](O)C)=O)CO)=O)=O)CC6=CN=CN6)=O)CC(O)=O)=O

Molecular Formula

C125H199N39O47S6

Molecular Weight

3192.54

References & Citations

[1]Christopher H Thompson, et al. Isolation and characterization of a high affinity peptide inhibitor of ClC-2 chloride channels.J Biol Chem

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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