Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

SRT 2183

SRT 2183 is a selective Sirtuin-1 (SIRT1) activator with an EC1.5 value of 0.36 μM[1]. SRT 2183 induces growth arrest and apoptosis, concomitant with deacetylation of STAT3 and NF-κB, and reduction of c-Myc protein levels[2].

Product Specifications

CAS Number

[1001908-89-9]

UNSPSC

12352005

Target

Apoptosis; Sirtuin

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/srt-2183.html

Purity

98.06

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(NC1=C(C2=CN3C(SC=C3CN4CC[C@@H](O)C4)=N2)C=CC=C1)C(C=C5)=CC6=C5C=CC=C6

Molecular Formula

C27H24N4O2S

Molecular Weight

468.57

References & Citations

[1]Milne JC, et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007 Nov 29; 450 (7170) : 712–716.|[2]Scuto A, et al. SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-κB/STAT3 complex to its promoter in malignant lymphoid cells. Cell Death Dis. 2013 May; 4 (5) : e635.|[3]Gurt I, et al. The Sirt1 Activators SRT2183 and SRT3025 Inhibit RANKL-Induced Osteoclastogenesis in Bone Marrow-Derived Macrophages and Down-Regulate Sirt3 in Sirt1 Null Cells. PLoS One. 2015 Jul 30;10 (7) :e0134391.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-19759/SRT-2183-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-19759/SRT-2183-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

SIRT1

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Ethyl 1H-1,2,3-triazole-4-carboxylate
OR917782-01 250 mg

Ethyl 1H-1,2,3-triazole-4-carboxylate

Ask
View Details
Ethyl 1H-1,2,3-triazole-4-carboxylate
OR917782-02 1 g

Ethyl 1H-1,2,3-triazole-4-carboxylate

Ask
View Details
Ethyl 1H-1,2,3-triazole-4-carboxylate
OR917782-03 5 g

Ethyl 1H-1,2,3-triazole-4-carboxylate

Ask
View Details
Ethyl 1H-1,2,3-triazole-4-carboxylate
OR917782-04 25 g

Ethyl 1H-1,2,3-triazole-4-carboxylate

Ask
View Details
DIXDC1 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)
18255066 1.0 µg DNA

DIXDC1 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)

Ask
View Details
SARS-CoV-2 (2019-nCoV) Nucleocapsid Monoclonal Antibody, AbBy Fluor™ 488 Conjugated
bsm-41482M-BF488 100 µL

SARS-CoV-2 (2019-nCoV) Nucleocapsid Monoclonal Antibody, AbBy Fluor™ 488 Conjugated

Ask
View Details