(1S,2S) -2-PCCA (hydrochloride)

(1S,2S) -2-PCCA hydrochloride is a less active diastereomer of 2-PCCA. 2-PCCA is a GPR88 receptor agonist, and inhibits GPR88-mediated cAMP production, with an EC50 of 116 nM in HEK293 cells.

Product Specifications

CAS Number

[1609563-70-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Isomer; GPR88

Type

Reference compound

Related Pathways

GPCR/G Protein; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/_1S,2S_-2-PCCA_hydrochloride_.html

Purity

99.65

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC[C@H](C)[C@H](N)CN(C1=CC=C(C2=CC=C(C=C2)CCC)C=C1)C([C@@H]3[C@@H](C4=CC=CC=N4)C3)=O.Cl.Cl

Molecular Formula

C30H39Cl2N3O

Molecular Weight

528.56

Precautions

H302, H315, H319, H335

References & Citations

[1]Jin C, et al. Synthesis, pharmacological characterization, and structure-activity relationship studies of small molecular agonists for the orphan GPR88 receptor. ACS Chem Neurosci. 2014 Jul 16;5 (7) :576-87.