(1S,2S) -2-PCCA (hydrochloride)
(1S,2S) -2-PCCA hydrochloride is a less active diastereomer of 2-PCCA. 2-PCCA is a GPR88 receptor agonist, and inhibits GPR88-mediated cAMP production, with an EC50 of 116 nM in HEK293 cells.
Product Specifications
CAS Number
[1609563-70-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Drug Isomer; GPR88
Type
Reference compound
Related Pathways
GPCR/G Protein; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/_1S,2S_-2-PCCA_hydrochloride_.html
Purity
99.65
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC[C@H](C)[C@H](N)CN(C1=CC=C(C2=CC=C(C=C2)CCC)C=C1)C([C@@H]3[C@@H](C4=CC=CC=N4)C3)=O.Cl.Cl
Molecular Formula
C30H39Cl2N3O
Molecular Weight
528.56
Precautions
H302, H315, H319, H335
References & Citations
[1]Jin C, et al. Synthesis, pharmacological characterization, and structure-activity relationship studies of small molecular agonists for the orphan GPR88 receptor. ACS Chem Neurosci. 2014 Jul 16;5 (7) :576-87.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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