Lazabemide
Lazabemide (Ro 19-6327) is a selective, reversible inhibitor of monoamine oxidase B (MAO-B) (IC50=0.03 μM) but less active for MAO-A (IC50>100 μM) . Lazabemide inhibits monoamine uptake at high concentrations, the IC50 values are 86 μM, 123 μM and >500 μM for noradrenalin, serotonin and dopamine uptake, respectively. Lazabemide can be used for the research of parkinson and alzheimer′s disease[1].
Product Specifications
CAS Number
103878-84-8
Product Name Alternative
Ro 19-6327
UNSPSC
12352005
Hazard Statement
H302, H319
Target
Monoamine Oxidase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Lazabemide.html
Purity
99.95
Solubility
DMSO : 5 mg/mL (ultrasonic)
Smiles
ClC1=CC=C(C(NCCN)=O)N=C1
Molecular Formula
C8H10ClN3O
Molecular Weight
199.64
Precautions
H302, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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