DOTA-amide (dihydrate)
DOTA-amide (dihydrate) is a Bifunctional Chelators (BFCs) . DOTA-amide (dihydrate) binds to the Affibody molecule ZHER2:S1. Its complex binds specifically to HER2 and can be used to detect bone metastases, which are common in prostate cancer[1].
Product Specifications
UNSPSC
12352200
Target
Biochemical Assay Reagents
Type
Biochemical Assay Reagents
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dota-amide-dihydrate.html
Solubility
10 mM in DMSO
Smiles
O=C(N)CN1CCN(CC(N)=O)CCN(CC(N)=O)CCN(CC(N)=O)CC1.O.O
Molecular Formula
C16H36N8O6
Molecular Weight
436.51
References & Citations
[1]Malmberg J, et al.Comparative evaluation of synthetic anti-HER2 Affibody molecules site-specifically labelled with 111In using N-terminal DOTA, NOTA and NODAGA chelators in mice bearing prostate cancer xenografts. Eur J Nucl Med Mol Imaging. 2012 Mar;39 (3) :481-92
Shipping Conditions
Room temperature
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported
Curated Selection
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