DOTA-amide (dihydrate)

DOTA-amide (dihydrate) is a Bifunctional Chelators (BFCs) . DOTA-amide (dihydrate) binds to the Affibody molecule ZHER2:S1. Its complex binds specifically to HER2 and can be used to detect bone metastases, which are common in prostate cancer[1].

Product Specifications

UNSPSC

12352200

Target

Biochemical Assay Reagents

Type

Biochemical Assay Reagents

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dota-amide-dihydrate.html

Solubility

10 mM in DMSO

Smiles

O=C(N)CN1CCN(CC(N)=O)CCN(CC(N)=O)CCN(CC(N)=O)CC1.O.O

Molecular Formula

C16H36N8O6

Molecular Weight

436.51

References & Citations

[1]Malmberg J, et al.Comparative evaluation of synthetic anti-HER2 Affibody molecules site-specifically labelled with 111In using N-terminal DOTA, NOTA and NODAGA chelators in mice bearing prostate cancer xenografts. Eur J Nucl Med Mol Imaging. 2012 Mar;39 (3) :481-92