Tyr-W-MIF-1
Tyr-W-MIF-1 is an opioid tetrapeptide with opiate and antiopiate activity. Tyr-W-MIF-1 can induce analgesia[1][2][5].
Product Specifications
CAS Number
144450-13-5
UNSPSC
12352209
Target
Opioid Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tyr-w-mif-1.html
Solubility
10 mM in DMSO
Smiles
O=C(NCC(N)=O)[C@@H](NC([C@H](CCC1)N1C([C@@H](N)CC(C=C2)=CC=C2O)=O)=O)CC3=CNC4=CC=CC=C34
Molecular Formula
C27H32N6O5
Molecular Weight
520.58
References & Citations
[1]Yang YR, et L. Opioid and antiopioid actions of Tyr-MIF-1, Tyr-W-MIF-1 and hemorphin-4 on rat locus coeruleus neurons: intracellular recording in vitro. Chin J Physiol. 1997 Sep 30;40 (3) :131-5. |[2]Gergen KA, et al. Expression of the FOS proto-oncogene protein in brain after ICV administration of Tyr-W-MIF-1 (Tyr-Pro-Trp-Gly-NH2) . Peptides. 1994;15 (8) :1505-11. |[3]Gergen KA, et al. Intrathecal Tyr-W-MIF-1 produces potent, naloxone-reversible analgesia modulated by alpha 2-adrenoceptors. Eur J Pharmacol. 1996 Mar 18;298 (3) :235-9. |[4]Harrison LM, et al. Tyr-W-MIF-1 attenuates down-regulation of opiate receptors in SH-SY5Y human neuroblastoma cells. J Pharmacol Exp Ther. 1998 Feb;284 (2) :611-7. |[5]Erchegyi J, et al. Isolation of a novel tetrapeptide with opiate and antiopiate activity from human brain cortex: Tyr-Pro-Trp-Gly-NH2 (Tyr-W-MIF-1) . Peptides. 1992 Jul-Aug;13 (4) :623-31.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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