ARS-1630
ARS-1630, a less active enantiomer of ARS-1620, is a novel inhibitor of mutant K-ras G12C extracted from patent WO 2015054572 A1.
Product Specifications
CAS Number
[1698055-86-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ARS-1630.html
Purity
98.10
Solubility
DMSO : ≥ 100 mg/mL
Smiles
C=CC(N1CCN(C2=C3C=C(Cl)[C@@]([C@@]4=C(O)C=CC=C4F)=C(F)C3=NC=N2)CC1)=O.[R]
Molecular Formula
C21H17ClF2N4O2
Molecular Weight
430.84
Precautions
H302, H315, H319, H335
References & Citations
[1]Liansheng Li, et al. Inhibitors of kras g12c. WO 2015054572 A1.|[2]Janes MR, et al. Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor. Cell. 2018 Jan 25;172 (3) :578-589.e17.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
Available Sizes
Curated Selection
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