R243

R243 is a potent and selective CCR8 antagonist. R243 inhibits CCL1/CCR8 interaction and inhibits CCR8 signaling and chemotaxis. R243 has antinociceptive and anti-inflammatory effects[1][2].

Product Specifications

CAS Number

[688352-84-3]

UNSPSC

12352005

Target

CCR

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/r243.html

Concentration

10mM

Purity

98.09

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

[C@@H]12CC(C[C@H](C3)C1)(C[C@@H]3C2)OCCN4CC(C=C(OCO5)C5=C6)=C6OC4

Molecular Formula

C21H27NO4

Molecular Weight

357.44

References & Citations

[1]Tomoyuki Oshio, et al. Chemokine Receptor CCR8 Is Required for Lipopolysaccharide-Triggered Cytokine Production in Mouse Peritoneal Macrophages. PLoS One. 2014 Apr 8;9 (4) :e94445.|[2]Mario García-Domínguez, et al. The Systemic Administration of the Chemokine CCL1 Evokes Thermal Analgesia in Mice Through the Activation of the Endocannabinoid System. Cell Mol Neurobiol. 2019 Nov;39 (8) :1115-1124.