PF-07038124 (hydrochloride)

PF-07038124 hydrochloride is a PDE4 inhibitor with an IC50 of 0.5 nM for PDE4B2. PF-07038124 hydrochloride shows inhibitory activities against IL-13, IL4, and IFNγ (IC50=125, 4.1, 1.06 nM, respectively) . PF-07038124 hydrochloride can be used for research of atopic dermatitis and plaque psoriasis[1][2].

Product Specifications

CAS Number

[2415317-57-4]

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pf-07038124-hydrochloride.html

Purity

99.26

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

[H]Cl.CCCOC1=C(OC)C=CC(C2=CN=CC([C@@]3([H])CB(OC3)O)=C2)=C1

Molecular Formula

C18H23BClNO4

Molecular Weight

363.64

References & Citations

[1]Boron containing pde4 inhibitors.WO2020070651A1.|[2]Eichenfield LF, et al. Efficacy and Safety of PF-07038124 in Patients With Atopic Dermatitis and Plaque Psoriasis: A Randomized Clinical Trial. JAMA Dermatol. 2024 Feb 1;160 (2) :156-163.