Nedaplatin
Nedaplatin (NSC 375101D) is a derivative of cisplatin and DNA damage agent.
Product Specifications
CAS Number
[95734-82-0]
Product Name Alternative
NSC 375101D
UNSPSC
12352211
Hazard Statement
H300, H315, H317, H319, H334, H335, H350
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Nedaplatin.html
Purity
98.0
Solubility
DMF : < 1 mg/mL|H2O : 8.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C[O-][Pt+2](N)(N)[O-]1
Molecular Formula
C2H8N2O3Pt
Molecular Weight
303.18
Precautions
H300, H315, H317, H319, H334, H335, H350
References & Citations
[1]Kanzawa, F., et al., In vitro synergistic interactions between the cisplatin analogue nedaplatin and the DNA topoisomerase I inhibitor irinotecan and the mechanism of this interaction. Clin Cancer Res, 2001. 7 (1) : p. 202-9.|[2]Uchida, N., et al., Sequence-dependent antitumour efficacy of combination chemotherapy of nedaplatin, a novel platinum complex, with 5-fluorouracil in an in vivo murine tumour model. Eur J Cancer, 1998. 34 (11) : p. 1796-801.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
Curated Selection
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